Pathology and Genetics of Tumors of the Urinary System and Male Genitals (WHO, 2004) WW.pdf

World Health Organization Classification of Tumours

WHO

OMS

International Agency for Research on Cancer (IARC)

Pathology and Genetics of

Tumours of the Urinary System

and Male Genital Organs

Edited by

John N. Eble

Guido Sauter

Jonathan I. Epstein

Isabell A. Sesterhenn

IARCPress

Lyon, 2004

World Health Organization Classification of Tumours

Series Editors Paul Kleihues, M.D.

Leslie H. Sobin, M.D.

Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs

Editors

John N. Eble, M.D.

Guido Sauter, M.D.

Jonathan I. Epstein, M.D.

Isabell A. Sesterhenn, M.D.

Coordinating Editors

Figen Soylemezoglu, M.D.

Wojciech Biernat, M.D.

Editorial Assistant

Stéphane Sivadier

Layout

Lauren A. Hunter

Allison L. Blum

Lindsay S. Goldman

Illustrations

Thomas Odin

Printed by

Team Rush

69603 Villeurbanne, France

Publisher

IARCPress

International Agency for

Research on Cancer (IARC)

69008 Lyon, France

This volume was produced in collaboration with the

International Academy of Pathology (IAP)

The WHO Classification of Tumours of the Urinary System and Male Genital

Organs presented in this book reflects the views of a Working Group that

convened for an Editorial and Consensus Conference in Lyon, France,

December 14-18, 2002.

Members of the Working Group are indicated

in the List of Contributors on page 299.

The WHO Working Group on Tumours of the Urinary System and Male Genital Organs

pays tribute to Dr F. Kash Mostofi (1911-2003), outstanding pathologist, who through his

vision, teachings and personality influenced generations of physicians worldwide.

Published by IARC Press, International Agency for Research on Cancer,

150 cours Albert Thomas, F-69008 Lyon, France

Publications of the World Health Organization enjoy copyright protection in

accordance with the provisions of Protocol 2 of the Universal Copyright Convention.

The International Agency for Research on Cancer welcomes

requests for permission to reproduce or translate its publications, in part or in full.

Requests for permission to reproduce figures or charts from this publication should be directed to

the respective contributor (see section Source of Charts and Photographs).

The designations used and the presentation of the material in this publication do not imply the

expression of any opinion whatsoever on the part of the Secretariat of the

World Health Organization concerning the legal status of any country, territory, city,

or area or of its authorities, or concerning the delimitation of its frontiers or boundaries.

The mention of specific companies or of certain manufacturers' products does not imply

that they are endorsed or recommended by the World Health Organization in preference to others

of a similar nature that are not mentioned. Errors and omissions excepted,

the names of proprietary products are distinguished by initial capital letters.

The authors alone are responsible for the views expressed in this publication.

Enquiries should be addressed to the

Communications Unit, International Agency for Research on Cancer, 69008 Lyon, France,

which will provide the latest information on any changes made to the text and plans for new editions.

Format for bibliographic citations:

Eble J.N., Sauter G., Epstein J.I., Sesterhenn I.A. (Eds.): World Health Organization

Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System

and Male Genital Organs. IARC Press: Lyon 2004

IARC Library Cataloguing in Publication Data

Pathology and genetics of tumours of the urinary system and male genital organs /

editors J.N. Eble… [et al.]

(World Health Organization classification of tumours ; 6)

1. Bladder neoplasms - genetics 2. Bladder neoplasms - pathology

3. Genital neoplasms, male - genetics 4. Genital neoplasms, male - pathology

5. Kidney neoplasms - genetics 6. Kidney neoplasms - pathology

7. Prostatic neoplasms – genetics 8. Prostatic neoplasms - pathology

I. Eble, John N. II. Series

ISBN 92 832 2412 4 (NLM Classification: WJ 160)

Contents

1 Tumours of the kidney

Primitive neuroectodermal tumour

(Ewing sarcoma)

WHO and TNM classifications

Neuroblastoma

Renal cell carcinoma

Paraganglioma / Phaeochromocytoma

Familial renal cancer

Lymphomas

Clear cell renal cell carcinoma

Plasmacytoma

Multilocular cystic renal cell

Leukaemia

Papillary renal cell carcinoma

Germ cell tumours

Chromophobe renal cell carcinoma

Carcinoma of the collecting ducts of Bellini

2 Tumours of the urinary system

Renal medullary carcinoma

Renal carcinomas associated with Xp11.2

translocations / TFE3 gene fusions

WHO and TNM classifications

Infiltrating urothelial carcinoma

Renal cell carcinoma associated with

neuroblastoma

Non-invasive urothelial tumours

110

Urothelial hyperplasia

111

Mucinous tubular spindle cell carcinoma

Urothelial dysplasia

111

Papillary adenoma of the kidney

Urothelial papilloma

113

Oncocytoma

Inverted papilloma

114

Renal cell carcinoma unclassified

Papillary urothelial neoplasm of low

malignant potential

Metanephric tumours

Metanephric adenoma

115

Non-invasive high grade papillary

urothelial carcinoma

Metanephric adenofibroma

117

Metanephric adenosarcoma

Urothelial carcinoma in situ

119

Metanephric stromal tumour

Genetics and predictive factors

120

Nephroblastic tumours

Nephroblastoma 48

Nephrogenic rests and nephroblastomatosis 53

Cystic, partially differentiated nephroblastoma 55

Soft tissue tumours

Clear cell sarcoma

Squamous neoplasms

Squamous cell carcinoma

124

Verrucous squamous cell carcinoma

127

Squamous cell papilloma

127

Glandular neoplasms

Adenocarcinoma

128

Rhabdoid tumour

Urachal carcinoma

131

Congenital mesoblastic nephroma

Clear cell adenocarcinoma

133

Ossifying renal tumour of infancy

Villous adenoma

134

Haemangiopericytoma

Neuroendocrine tumours

Small cell carcinoma

Leiomyosarcoma

135

Osteosarcoma

Paraganglioma

136

Renal angiosarcoma

Carcinoid

138

Malignant fibrous histiocytoma

Soft tissue tumours

Rhabdomyosarcoma

Angiomyolipoma

139

Epithelioid angiomyolipoma

Leiomyosarcoma

140

Leiomyoma

Angiosarcoma

141

Haemangioma

Osteosarcoma

142

Lymphangioma

Malignant fibrous histiocytoma

143

Juxtaglomerular cell tumour

Leiomyoma

144

Renomedullary interstitial cell tumour

Other mesenchymal tumours

144

Intrarenal schwannoma

Granular cell tumour

145

Solitary fibrous tumour

Neurofibroma

145

Cystic nephroma

Haemangioma

146

Mixed epithelial and stromal tumour

Malignant melanoma

146

Synovial sarcoma

Lymphomas

147

Neural / neuroendocrine tumours

Renal carcinoid tumour

Metastatic tumours and secondary extension

148

Tumours of the renal pelvis and ureter

150

Neuroendocrine carcinoma

Tumours of the urethra

154

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