Science - April 28 2006.pdf

(19566 KB) Pobierz
untitled
28 April 2006 | $10
443927964.008.png
length &
Met 4.2kb · FRAP1 7.7kb · PIK3CA
IGF1R 4.1kb · FLT1 4.0kb · TRPM8
ERBB5 3.9kb · ABL1 3.4kb · SLIT3
· PTPRB 6.0kb · NCOA6 6.2kb · EP
7.2kb · F8 7.1kb · PRPF8 7.0kb · AK
7.0kb · TP53BP1 6.0kb · RICS 5.2k
C42BPB 6.9kb · ATM 5.1kb · TJP1
CDC42BPA 4.9kb · MADD 4.8kb ·
4.5kb · LRRK2 7.6kb · EP300 7.2k
F8 7.1kb · PRPF8 7.0kb · AKAP6 7
PTPRZ1 6.9kb · GOLGA4 6.7kb · K
6.6kb · ESPL1 6.4kb · NCOA6 6.2k
PIK4CA 6.1kb · MPDZ 6.1kb · PHF3
· TRPM6 6.1kb · ch-TOG 5.9kb · TP
5.9kb · MYH7 5.8kb · DICER1 5.8k
PTPRF 5.7kb · ZFP106 5.7kb · BIG
· ITGB4 5.5kb · LAMA4 5.5kb · TS
5.4kb · PRKWNK3 5.4kb · LAMB2
· SVIL 5.4kb · AKAP12 5.3kb · KIA
5.3kb · RICS 5.2kb · ADPRTL1 5.2
LY75 · 5.2 · CDC42BPB 5.1kb · ATM
· CENTD1 5.1kb · AKAP12 5.1kb · CL
5.0 · CORTBP2 5.0kb · IQGAP1 5.0
· KIAA0191 4.9kb · CDC42BPA 4.9
LRP5 4.8kb · LRP6 4.8kb · ROBO
· LAMC1 4.8kb · USP32 4.8kb · RB
4.8kb · PEG3 4.8kb · EIF4G3 4.8k
KAB 4.8kb · GCC2 4.8kb · MADD
· TRPM3 4.7kb · ABCC2 4.6kb · PL
4.6kb · SETBP1 4.6kb · ZFYVE16 4
SMCY 4.6kb · AGL 4.6kb · ABCC1
· SLIT2 4.6kb · ABCC3 4.6kb · SLI
difculty?
We’ve already done them for you. OriGene’s
TrueClone collection
has over 24,000 ready-cloned
non-PCR human full-length cDNAs in CMV vectors,
set for overnight delivery.
TrueClone contains more large, rare, and
GC-rich genes than any other sources
Directly isolated from a human cDNA library;
no PCR artifacts
Conrmed Both 5’ and 3’ ends of the insert have
been sequenced and are published on the website
Expression-Ready Ready to be transfected
into mammalian cells for protein expression
and functional studies
Most clones can be
delivered overnight to your laboratory
as puried plasmid
888-2-origene (888-267-4436) · www.origene.com
cloning genes of great
Comprehensive
Authentic
Quick Delivery
443927964.009.png
GE Healthcare
Bringing
science to life
When it comes to life sciences, GE Healthcare is setting the
standard. Tens of thousands of scientists in over 100 countries
around the world rely on our products every day. We have
delivered more than 60 000 research protein purification systems,
1500 BioProcess ™ systems and 12 000 BioProcess columns
worldwide. Our Amersham family of consumables, with its 60-year
heritage, is trusted to provide accurate results time and time again.
But we’re never content to stand still. We constantly strive for
new innovations for tomorrow’s research and drug development.
And the result is groundbreaking products like the ÄKTAdesign ™
platform, IN Cell Analyzer, Ad-A-Gene Vectors, and MabSelect ™
media. Thanks to our technological achievements and global
presence, we’re able to help you turn your scientific ideas into
reality – bringing science to life and helping transform healthcare.
We call it Life Science Re-imagined.
Discover more at www.gehealthcare.com/life
443927964.001.png
CONTENTS
Volume 312, Issue 5773
COVER
View of Santorini, Greece, from Fira.
Across the volcanic caldera, the Nea and
Palea Kameni islands (middle right) have
been volcanically active since 197 B.C.
The Akrotiri peninsula (top left) was an area
of major Bronze Age settlement that was
destroyed but preserved by the Minoan
eruption in the late 17th century B.C.
See pages 548 and 565 .
Photo: Sturt Manning
DEPARTMENTS
495
496
500
502
505
507
525
542
601
602
EDITORIAL
499
by J. Michael Bishop and Harold Varmus
508
526
509
D. D. Goble
A Scientific Supercourse R. E. Laporte et al.
Marine Parks Need Sharks? D. D. F. Chapman et al.
Response P. J. Mumby et al.
A Not-So-Abrupt Departure M. E. Mann and M. K. Hughes
Mechanisms for Resistance in Soil S. B. Levy ; R. W. Pickup
and G. Rhodes
511
511
512
512
530
513
A. Burt and R. Trivers, reviewed by P. Hammerstein
and E. H. Hagen
514
514
531
515
P. Ormerod, reviewed by S. Kean
534
532
516
T. de Jong
518
522
534
C. Miller
>> Report p. 589
523
535
A. Fitzsimmons
>> Report p. 561
536
537
539
E. P. J. van den Heuvel
>> Report p. 549
540
R. Jahn
>> Report p. 592
518
CONTENTS
>>
www.sciencemag.org SCIENCE VOL 312 28 APRIL 2006
489
443927964.002.png 443927964.003.png 443927964.004.png 443927964.005.png 443927964.006.png 443927964.007.png
Zgłoś jeśli naruszono regulamin