Andrew.W._-_Pharmaceutical_Manufacturing_encyclopedia_v.1.pdf

PHARMACEUTICAL

MANUFACTURING

ENCYCLOPEDIA

A through B

Volume 2

C through G

Volume 3

H through P

Q through Z

Raw Materials Index

Trade Names Index

Third Edition

Volume 1

Volume 4

any form or by any means, electronic or mechanical, including photocopying, recording, or by any

information storage and retrieval system, without permission in writing from the Publisher, with the

exception of the following:

Cover by Brent Beckley

Library of Congress Cataloging-in-Publication Data

Pharmaceutical manufacturing encyclopedia. -- 3rd ed.

p. ; cm.

Rev. ed. of: Pharmaceutical manufacturing encyclopedia / by Marshall

Sittig. c1988.

Includes bibliographical references and index.

ISBN-13: 978-0-8155-1526-5 (set : alk. paper)

ISBN-10: 0-8155-1526-X (set : alk paper)

1. Drugs--Synthesis--Dictionaries. 2. Pharmaceutical

chemistry--Dictionaries. I. Sittig, Marshall. Pharmaceutical manufacturing

encyclopedia. II. William Andrew Publishing.

[DNLM: 1. Pharmaceutical Preparations--Encyclopedias--English. 2.

Chemistry, Pharmaceutical--Encyclopedias--English. QV 13 P536 2007]

RS402.5.S58 2007

615'.19--dc22

2006023472

Printed in India

This book is printed on acid-free paper.

10 9 8 7 6 5 4 3 2 1

Published by:

William Andrew Publishing

13 Eaton Avenue

Norwich, NY 13815

1-800-932-7045

www.williamandrew.com

Exclusively distributed in the Indian Subcontinent by Affiliated East-West Press Pvt. Ltd., G-1/16,

Ansari Road, Darya Ganj, New Delhi 110 002

NOTICE

To the best of our knowledge the information in this publication is accurate; however the Publisher

does not assume any responsibility or liability for the accuracy or completeness of, or consequences

arising from, such information. This book is intended for informational purposes only. Mention of

trade names or commercial products does not constitute endorsement or recommendation for their

use by the Publisher. Final determination of the suitability of any information or product for any use,

and the manner of that use, is the sole responsibility of the user. Anyone intending to rely upon any

recommendation of materials or procedures mentioned in this publication should be independently

satisfied as to such suitability, and must meet all applicable safety and health standards.

Preface

The Third Edition of Pharmaceutical Manufacturing

Encyclopedia contains descriptions of manufacturing processes,

structural formulas, trade names, therapeutic functions, and other

information on 2266 pharmaceuticals now being marketed as

trade-named products in America and many other countries.

Information on 1295 pharmaceuticals has been taken from the

Second Edition of the Pharmaceutical Manufacturing

Encyclopedia (Marshall Sittig, Noyes Publications, Westwood,

New Jersey, USA, 1986). Information on 971 additional

pharmaceuticals, including those approved by the U.S. Food and

Drug Administration (FDA) since 1986, are included in the

Encyclopedia as well.

The Encyclopedia comprises 4 volumes:

Volume 1: A through B

Volume 2: C through G

Volume 3: H through P

Volume 4: Q through Z, and the Raw Materials and Trade

Names Indexes.

The pharmaceuticals are listed in alphabetical order.

INFORMATION SOURCES USED

For the Second Edition, a variety of sources were used to identify

the patents associated with particular commercial products and to

serve as a source of process information. The sources included the

following:

Merck Index : followed by a citation of the entry number in the

Tenth (1983) Edition. 1

DFU : The periodical publication, Drugs of the Future, 3 published

by Prous Science .

DOT : The periodical publication, Drugs of Today , 4 published by

Prous Science .

Kleeman & Engel : The encyclopedic German work,

Pharmazeutische Werkstoffe, 5 second revised edition published in

1982.

OCDS : The 3-volume reference series, The Organic Chemistry of

Drug Synthesis. 7

In addition, sources of pharmacological data and comparative

information on trade names used in various countries were

obtained from:

REM : Remington's Pharmaceutical Sciences. 9

Nonproprietary Name Index : The nonproprietary name index

published by Paul de Haen. 11

I.N. : The biannual Swiss publication, Index Nominum. 12

PDR : The guide to commercially available U.S. drugs, the

Physicians' Desk Reference . 13

For the Third Edition, a number of new and updated sources

were used, including the latest edition of The Merck Index. 2

Extensive use has been made of the US, British, German, and

world patent literature with regard to the process information.

In addition, a variety of sources were used to identify the patents

associated with particular commercial products and to serve as a

source of process information. These include the encyclopedic

German work Pharmazeutische Wirkstoffe (4 th edition), edited by

A. Kleeman and J. Engel, 6 and the 6-volume reference series on

the Organic Chemistry of Drug Synthesis by Daniel Lednicer 8 and

references [ 10 ] through [ 14 ] below.

vii

In addition to the patent-derived process information, references to

major pharmaceutical reference works where additional

information can be obtained on synthesis methods and the

pharmacology of the individual products are also cited under each

drug entry.

Pharmacological data and comparative information on trade names

used in various countries were obtained from Organic-Chemical

Drugs and Their Synonyms, 8 th ed., by M. Negwer and H.-G.

Scharnow. 15

July 2006

References

1. Windholz, M., editor, The Merck Index , 10th ed. Rahway, NJ: Merck

& Co., Inc. (1983).

2. Smith, Ann, et al., The Merck Index: An Encyclopedia of Chemicals,

Drugs, & Biologicals , 13 th ed. Rahway, NJ: Merck & Co., Inc.

(2001).

3. Prous, J.R., editor, Drugs of the Future , Vol. 30. Barcelona, Spain:

Prous Science Publishers (2005)

4. Prous, J.R., editor. Drugs of Today , Vol. 41. Barcelona, Spain: Prous

Science Publishers (2005)

5. Kleeman, A. and Engel, J., Pharmazeutische Werkstoffe: Synthesen,

Patente, Anwendugen , Stuttgart, Germany: Georg Thieme Verlag,

(1982).

6. Kleeman A., Engel J. Pharmazeutische Wirkstoffe. English:

Pharmaceutical substances: syntheses, patents, applications , 4 th ed.

Stuttgart, Germany: Georg Thieme Verlag, (2001).

7. Lednicer, D., and Mitscher, L., The Organic Chemistry of Drug

Synthesis , New York: John Wiley and Sons. Vol. 1 (1977); Vol. 2

(1980); Vol. 3 (1984); Vol. 4 (1990).

8. Lednicer, D., The Organic Chemistry of Drug Synthesis , New York:

John Wiley and Sons. Vol. 4 (1990); Vol. 5 (1994); Vol. 6 (1998).

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