Microbial_Fundamentals_of_Biotechnology_(Wiley,_2002).pdf

(4136 KB) Pobierz
308474826 UNPDF
308474826.003.png
Deutsche
Forschungsgemeinschaft
Microbial Fundamentals
of Biotechnology
Microbial Fundamentals of Biotechnology. DFG, Deutsche Forschungsgemeinschaft
Copyright © 2001 WILEY-VCH Verlag GmbH, Weinheim
ISBN: 3-527-30615-3
308474826.004.png 308474826.005.png
Deutsche
Forschungsgemeinschaft
Microbial Fundamentals
of Biotechnology
Final report of the
collaborative research centre 323,
„Mikrobielle Grundlagen der Biotechnologie:
Struktur, Biosynthese und Wirkung mikrobieller
Stoffe“, 1986 – 1999
Edited by
Volkmar Braun and Friedrich Götz
Collaborative Research Centres
308474826.006.png 308474826.001.png
!
" #
"# $$%&''(&((
)*# $$%&''(&(('
+,# -./0# 1 2 " 2 3 2 4 2
+, -5 4 (''0# 6/
5# #&&777//
) 8 7 / 9: 7
/ : 8
: /
Cover:
Crystal structure of E.coli FhuA with bound rifamycin CGP 4832 as
determined by Ferguson et al. Structure 9:707-16 (2001)
; 4 4 9/#
3 8 : ; /
8<45"4"
3 : 8
519 '=
>5;+?@4A @ ! A > - !0 '
" /
3 : - 0/ 9 8
< <
7 7 /
8 / 8 : 7 8
7/
4# "1C D >
"# C8
8 # E/ 1F ! A G 4/ ! !B
" !
308474826.002.png
Contents
Antibiotics and Other Biologically Active Microbial Metabolites
1 Introduction ............................................ 3
Volkmar Braun and Friedrich Götz
Abstract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
1.1 Antibiotic research . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
1.2 The unique features of microbial iron transport . . . . . . . . . . . . . . . . 6
1.3 Transport of bacterial proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
1.4 Membrane components and membrane polarization . . . . . . . . . . . . 10
1.5 Chemistry of microbial peptides and proteins . . . . . . . . . . . . . . . . . 12
1.6 Summary of short-term projects of the collaborative research centre 14
2 Screening for New Secondary Metabolites from Microorganisms 16
Hans-Peter Fiedler and Hans Zähner
2.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16
2.2 Screening methods and novel compounds . . . . . . . . . . . . . . . . . . . . 18
2.3 Increasing structural diversity by directed fermentations . . . . . . . . . 41
Acknowledgments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47
3 Biosynthesis of the Lantibiotics Epidermin and Gallidermin ..... 52
Friedrich Götz and Günther Jung
3.1 History of lantibiotics and lantibiotic research in Tübingen . . . . . . . 52
3.2 Primary structure and proposed maturation of epidermin in
staphylococci . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55
3.3 Genetic organization and regulation of the epidermin genes . . . . . 56
3.4 Isolation and characterization of genetically engineered gallidermin
and epidermin analogues . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59
3.5 Function of the epidermin immunity genes epiFEG ............. 66
3.6 Inactivation and characterization of the epidermin leader peptidase
EpiP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 72
3.7 The flavoenzyme EpiD and formation of peptidyl-amino-
enethiolates . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 74
V
Microbial Fundamentals of Biotechnology. DFG, Deutsche Forschungsgemeinschaft
Copyright 2001 WILEY-VCH Verlag GmbH,Weinheim
ISBN: 3-527-30615-3

Plik z chomika:

Inne pliki z tego folderu:

Inne foldery tego chomika:

Zgłoś jeśli naruszono regulamin