Veterinary Formulary.doc

Veterinary Formulary

Comments:

Drug dosages listed are compiled and averaged from numerous sources (see RAR libraryfor more complete information.) If any problems are encountered with the listed doses, notify the Department of Comparative Medicine so that the dose can be evaluated and appropriate changes made to this manual. Drugs that are not commonly used may be referenced directly. Drugs and doses listed are those that were encountered during the literature search. Omission of a species dose does not imply that the drug can not be used in that species. 

Please note that animal welfare regulations prohibit the use of expired drugs on research animals, except if the animal is anesthetized for a terminal study.  The anesthesia drugs may not be expired under any circumstances. 

www.aphis.usda.gov/ac/policy/policy3.pdf

Pharmaceutical-Grade Compounds in Research

Investigators are expected to use pharmaceutical-grade medications whenever they are available, even in acute procedures. Non-pharmaceutical-grade chemical compounds should only be used in regulated animals after specific review and approval by the IACUC for reasons such as scientific necessity or non-availability of an acceptable veterinary or human pharmaceutical-grade product. Cost savings alone are not an adequate justification for using non-pharmaceutical-grade compounds in regulated animals.

Don't forget to follow the University Controlled Substances Policy

Some comments on drug combinations. Many drugs, especially anesthetics and sedatives are mixed in the syringe to achieve better effect than either drug alone. In general, for drugs of different therapeutic classes the doseages used are the same as either drug used individually. For drugs ofthe same therapeutic class, drugs may be synergistic, necessitating reduction of the dosages of individual drugs. Some frequently used combinations are listed here: 
 

Many drugs with TID dosage rates are used BID (especially antibiotics.) To calculate a BID dose, multiply the TID dose by three to arrive at a daily dose. Divide by two for the BID dose. This method may be used to arrive at any dosage interval including constant infusion rates. Bear in mind that the pharmacokinetics can vary greatly with dosing interval and the drug may be considerably less effective when this is changed. The pharmacokinetics of the drug should be investigated prior to making this assumption. 

Codes: CNS=central nervous system, NSAID=non-steroidal anti-inflammatory drug, IV=intravenous, IM=intramuscular, SQ=subcutaneous, IP=intraperitoneal, PO=orally, SID=once daily, BID=twice daily, TID=3 times daily, QID=4 times daily, Qxh or Qxd=once every x hours or days. C-II to V=DEA schedule classification. *=Drugs stocked by RAR. t=teaspoon, gal=gallon, IACUC=Institutional Animal Care and Use Committee. 

Drugs Listed By Therapeutic Class

*=Drugs typically stocked by RAR