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PHARMACEUTICAL
MANUFACTURING
ENCYCLOPEDIA
A through B
Volume 2
C through G
Volume 3
H through P
Q through Z
Raw Materials Index
Trade Names Index
Third Edition
Volume 1
Volume 4
Copyright © 2007 by William Andrew, Inc. No part of this book may be reproduced or utilized in
any form or by any means, electronic or mechanical, including photocopying, recording, or by any
information storage and retrieval system, without permission in writing from the Publisher, with the
exception of the following:
Cover by Brent Beckley
Library of Congress Cataloging-in-Publication Data
Pharmaceutical manufacturing encyclopedia. -- 3rd ed.
p. ; cm.
Rev. ed. of: Pharmaceutical manufacturing encyclopedia / by Marshall
Sittig. c1988.
Includes bibliographical references and index.
ISBN-13: 978-0-8155-1526-5 (set : alk. paper)
ISBN-10: 0-8155-1526-X (set : alk paper)
1. Drugs--Synthesis--Dictionaries. 2. Pharmaceutical
chemistry--Dictionaries. I. Sittig, Marshall. Pharmaceutical manufacturing
encyclopedia. II. William Andrew Publishing.
[DNLM: 1. Pharmaceutical Preparations--Encyclopedias--English. 2.
Chemistry, Pharmaceutical--Encyclopedias--English. QV 13 P536 2007]
RS402.5.S58 2007
615'.19--dc22
2006023472
Printed in India
This book is printed on acid-free paper.
10 9 8 7 6 5 4 3 2 1
Published by:
William Andrew Publishing
13 Eaton Avenue
Norwich, NY 13815
1-800-932-7045
www.williamandrew.com
Exclusively distributed in the Indian Subcontinent by Affiliated East-West Press Pvt. Ltd., G-1/16,
Ansari Road, Darya Ganj, New Delhi 110 002
NOTICE
To the best of our knowledge the information in this publication is accurate; however the Publisher
does not assume any responsibility or liability for the accuracy or completeness of, or consequences
arising from, such information. This book is intended for informational purposes only. Mention of
trade names or commercial products does not constitute endorsement or recommendation for their
use by the Publisher. Final determination of the suitability of any information or product for any use,
and the manner of that use, is the sole responsibility of the user. Anyone intending to rely upon any
recommendation of materials or procedures mentioned in this publication should be independently
satisfied as to such suitability, and must meet all applicable safety and health standards.
Preface
The Third Edition of Pharmaceutical Manufacturing
Encyclopedia
contains descriptions of manufacturing processes,
structural formulas, trade names, therapeutic functions, and other
information on 2266 pharmaceuticals now being marketed as
trade-named products in America and many other countries.
Information on 1295 pharmaceuticals has been taken from the
Second Edition of the
Pharmaceutical Manufacturing
Encyclopedia
(Marshall Sittig, Noyes Publications, Westwood,
New Jersey, USA, 1986). Information on 971
additional
pharmaceuticals, including those approved by the U.S. Food and
Drug Administration (FDA) since 1986, are included in the
Encyclopedia
as well.
The
Encyclopedia
comprises 4 volumes:
Volume 1: A through B
Volume 2: C through G
Volume 3: H through P
Volume 4: Q through Z, and the Raw Materials and Trade
Names Indexes.
The pharmaceuticals are listed in alphabetical order.
INFORMATION SOURCES USED
For the Second Edition,
a variety of sources were used to identify
the patents associated with particular commercial products and to
serve as a source of process information. The sources included the
following:
Merck Index
: followed by a citation of the entry number in the
Tenth (1983) Edition.
1
vi
DFU
: The periodical publication,
Drugs of the Future,
3
published
by
Prous Science
.
DOT
: The periodical publication,
Drugs of Today
,
4
published by
Prous Science
.
Kleeman & Engel
: The encyclopedic German work,
Pharmazeutische Werkstoffe,
5
second revised edition published in
1982.
OCDS
: The 3-volume reference series,
The
Organic Chemistry of
Drug Synthesis.
7
In addition, sources of pharmacological data and comparative
information on trade names used in various countries were
obtained from:
REM
:
Remington's Pharmaceutical Sciences.
9
Nonproprietary Name Index
: The nonproprietary name index
published by Paul de Haen.
11
I.N.
: The biannual Swiss publication,
Index Nominum.
12
PDR
: The guide to commercially available U.S. drugs, the
Physicians' Desk Reference
.
13
For the Third Edition,
a number of new and updated sources
were used, including the latest edition of The Merck Index.
2
Extensive use has been made of the US, British, German, and
world patent literature with regard to the process information.
In addition, a variety of sources were used to identify the patents
associated with particular commercial products and to serve as a
source of process information. These include the encyclopedic
German work
Pharmazeutische Wirkstoffe
(4
th
edition), edited by
A. Kleeman and J. Engel,
6
and the 6-volume reference series on
the
Organic Chemistry of Drug Synthesis
by Daniel Lednicer
8
and
references [
10
] through [
14
] below.
vii
In addition to the patent-derived process information, references to
major pharmaceutical reference works where additional
information can be obtained on synthesis methods and the
pharmacology of the individual products are also cited under each
drug entry.
Pharmacological data and comparative information on trade names
used in various countries were obtained from
Organic-Chemical
Drugs and Their Synonyms,
8
th
ed., by M. Negwer and H.-G.
Scharnow.
15
July 2006
References
1.
Windholz, M., editor,
The Merck Index
, 10th ed. Rahway, NJ: Merck
& Co., Inc. (1983).
2.
Smith, Ann, et al.,
The Merck Index: An Encyclopedia of Chemicals,
Drugs, & Biologicals
, 13
th
ed. Rahway, NJ: Merck & Co., Inc.
(2001).
3.
Prous, J.R., editor,
Drugs of the Future
, Vol. 30. Barcelona, Spain:
Prous Science Publishers (2005)
4.
Prous, J.R., editor.
Drugs of Today
, Vol. 41. Barcelona, Spain: Prous
Science Publishers (2005)
5.
Kleeman, A. and Engel, J.,
Pharmazeutische Werkstoffe: Synthesen,
Patente, Anwendugen
, Stuttgart, Germany: Georg Thieme Verlag,
(1982).
6.
Kleeman A., Engel J.
Pharmazeutische Wirkstoffe.
English:
Pharmaceutical substances: syntheses, patents, applications
, 4
th
ed.
Stuttgart, Germany: Georg Thieme Verlag, (2001).
7.
Lednicer, D., and Mitscher, L.,
The Organic Chemistry of Drug
Synthesis
, New York: John Wiley and Sons. Vol. 1 (1977); Vol. 2
(1980); Vol. 3 (1984); Vol. 4 (1990).
8.
Lednicer, D.,
The Organic Chemistry of Drug Synthesis
, New York:
John Wiley and Sons. Vol. 4 (1990); Vol. 5 (1994); Vol. 6 (1998).
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