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Page i
Genetics:
Principles and Analysis
Fourth Edition
Daniel L. Hartl
Harvard University
Elizabeth W. Jones
Carnegie Mellon University
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Page ii
TO THE BEST TEACHERS WE EVER HAD—OUR PARENTS AND OUR STUDENTS
ABOUT THE AUTHORS
Daniel L. Hartl is a Professor of Biology at Harvard University. He received his B.S. degree and
Ph.D. from the University of Wisconsin. His research interests include molecular genetics,
molecular evolution, and population genetics. Elizabeth W. Jones is a Professor of Biological
Sciences at Carnegie Mellon University. She received her B.S. degree and Ph.D. from the
University of Washington in Seattle. Her research interests include gene regulation and the genetic
control of cellular form. Currently she is studying the function and assembly of organelles in the
yeast Saccharomyces.
ABOUT THE COVER
A human chromosome.
ABOUT THE PUBLISHER
World Headquarters
Jones and Bartlett Publishers
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Sudbury, MA 01776
978-443-5000
info@jbpub.com
http://www.jbpub.com
Jones and Bartlett Publishers Canada
P.O. Box 19020
Toronto, ON M5S 1X1
CANADA
Jones and Bartlett Publishers International
Barb House, Barb Mews
London W6 7PA
UK
ABOUT THE BOOK
Chief Executive Officer: Clayton Jones
Chief Operating Officer: Don Jones, Jr.
Publisher: Tom Walker
V.P., Sales and Marketing: Rob McCarry
Senior Managing Editor: Judith H. Hauck
Marketing Director: Rich Pirozzi
Production Manager: Anne Spencer
Manufacturing Director: Jane Bromback
Executive Editor: Brian L. McKean
Project Editor: Kathryn Twombly
Senior Production Editor: Mary Hill
Web Site Design: Andrea Wasik
* * *
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Development Editor: Richard Morel
Book and Cover Design: J/B Woolsey Associates
Art Development and Rendering: J/B Woolsey Associates
Composition and Book Layout: Thompson Steele, Inc.
Prepress: Westwords, Inc.
Cover Manufacture: Coral Graphic Services, Inc.
Book Manufacture: World Color Book Services
Library of Congress Cataloging-in-Publication Data
Hartl, Daniel L.
Genetics: Principles and analysis / Daniel L. Hartl, Elizabeth W. Jones.—4th ed.
p. cm.
Includes bibliographical references (p.).
ISBN 0-7637-0489-X
1. Genetics. I. Jones, Elizabeth W. II. Title.
QH430.H3733 1998
576.5—dc21 97-40566
CIP
COPYRIGHT
ã
1998 BY JONES AND BARTLETT PUBLISHERS, INC.
All rights reserved. No part of the material protected by this copyright notice may be reproduced or
utilized in any form, electronic or mechanical, including photocopying, recording, or by any
information storage and retrieval system, without written permission from the copyright owner.
Printed in the United States
03 02 01 00 99 98 9 8 7 6 5 4 3 2
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Page iii
Brief Contents
Chapter 1
The Molecular Basis of Heredity and Variation
1
Chapter 2
Principles of Genetic Transmission
30
Chapter 3
Genes and Chromosomes
80
Chapter 4
Genetic Linkage and Chromosome Mapping
122
Chapter 5
The Molecular Structure and Replication of the Genetic Material
172
Chapter 6
The Molecular Organization of Chromosomes
220
Chapter 7
Variation in Chromosome Number and Structure
258
Chapter 8
The Genetics of Bacteria and Viruses
306
Chapter 9
Genetic Engineering and Genome Analysis
358
Chapter 10
Gene Expression
410
Chapter 11
Regulation of Gene Activity
458
Chapter 12
The Genetic Control of Development
510
Chapter 13
Mutation, DNA Repair, and Recombination
554
Chapter 14
Extranuclear Inheritance
598
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